Types

• Side effects associated with Aleve include skin rashes, ringing in your ears, constipation, heartburn, abdominal pain, nausea, indigestion, diarrhea, vomiting and shortness of breath.
  
  

Time Frame

• Some of the side effects of Aleve develop when you first begin treatment and diminish over time as your body becomes acclimated to the effects of the drug, according to the Mayo Clinic.
  
  

Drug Interactions

• When combined with blood thinning medications such as warfarin, Aleve increases your risk of developing prolonged or uncontrollable bleeding, reports Drugs.com. Aleve increases your risk of developing side effects from the arthritis medication methotrexate.
  
  

Risks

• Like other non-steroidal anti-inflammatory medications, Aleve poses a risk for digestive ulcers, which may cause bleeding or the formation of holes or perforations in your stomach or intestines, warns the American College of Gastroenterolgy. Additionally, long-term use of NSAIDs increases your risk of developing heart disease, according to the U.S. Food and Drug Administration.
  
  

Considerations

• Because its effects upon fetal development are unknown, doctors recommend that pregnant women avoid using naproxen drugs like Aleve unless there is no safe alternative to treatment. If you have a history of anemia, bleeding problems, blood clots, edema, heart attack, heart disease, hypertension, kidney or liver disease, digestive ulcers, stroke, aspirin allergies or have recently undergone heart bypass surgery, it may not be safe for you to take Aleve, cautions the Mayo Clinic.