Dietary Sodium Restriction: A Therapeutic Opportunity in CKD
Dietary Sodium Restriction: A Therapeutic Opportunity in CKD
In CKD, blood pressure is usually sodium sensitive. Moreover, renal protein loss is reduced by dietary sodium restriction. This has been shown for sodium restriction as a single measure, as well as for sodium restriction as an add-on to antihypertensive treatment. Interestingly, proteinuria reduction by sodium restriction remains significant after adjustment for the fall in blood pressure, suggesting an independent renoprotective effect of sodium restriction, both as a single measure and in combination with blockade of the renin–angiotensin–aldosterone system (RAAS). A blood pressure-independent effect of dietary sodium on the kidney is substantiated by data in healthy volunteers, in which dietary sodium restriction reduces albuminuria within the normal range, without a detectable effect on blood pressure.
Effect of Dietary Sodium Restriction in Chronic Kidney Disease Patients
In CKD, blood pressure is usually sodium sensitive. Moreover, renal protein loss is reduced by dietary sodium restriction. This has been shown for sodium restriction as a single measure, as well as for sodium restriction as an add-on to antihypertensive treatment. Interestingly, proteinuria reduction by sodium restriction remains significant after adjustment for the fall in blood pressure, suggesting an independent renoprotective effect of sodium restriction, both as a single measure and in combination with blockade of the renin–angiotensin–aldosterone system (RAAS). A blood pressure-independent effect of dietary sodium on the kidney is substantiated by data in healthy volunteers, in which dietary sodium restriction reduces albuminuria within the normal range, without a detectable effect on blood pressure.