Uremic Pruritus Review
Uremic Pruritus Review
The etiology of UP imperfectly understood. Studies have shown that patients with severe pruritus are male and have a high predialysis concentration of blood urea nitrogen, hypercalcemia, hyperphosphatemia, secondary hyperparathyroidism, and hypermagnesemia. Medications that may contribute to the development of UP have also been investigated. Of note, ACE inhibitor treatment has been associated with UP, whereas in patients without UP furosemide treatment is more common. A possible explanation for this is the adverse effect (AE) of pruritus from ACE inhibitor treatment.
Etiology
The etiology of UP imperfectly understood. Studies have shown that patients with severe pruritus are male and have a high predialysis concentration of blood urea nitrogen, hypercalcemia, hyperphosphatemia, secondary hyperparathyroidism, and hypermagnesemia. Medications that may contribute to the development of UP have also been investigated. Of note, ACE inhibitor treatment has been associated with UP, whereas in patients without UP furosemide treatment is more common. A possible explanation for this is the adverse effect (AE) of pruritus from ACE inhibitor treatment.
