Unusual Histopathological Diagnosis of Prostatic Blue Nevus
Unusual Histopathological Diagnosis of Prostatic Blue Nevus
Introduction: Prostatic blue nevus was first described as a benign lesion of uncertain and controversial histogenesis by Nogogosyan in 1963. Currently, 30 cases have been reported in the world literature.
Case presentation: A 63-year-old Hispanic man presented with prostatism of several months' evolution. Histopathological examination revealed a blue nevus associated with nodular hyperplasia and acute inflammation.
Conclusion: Prostatic blue nevus is a rare and unusual, histologically benign prostatic lesion with limited clinical significance and a favorable prognosis.
Melanocytic lesions, comprising blue nevi (BN), melanosis and malignant melanomas, are neoplastic processes observed, though rarely, in the prostate gland. Extracutaneous location of a BN is extremely unusual. There have been reports of BN in the spermatic cord, prostate, vagina, cervix, oral cavity, paranasal sinuses, larynx, breast, pulmonary hilum and lymph nodes.
Prostatic blue nevus (PBN), first described in 1963 by Nogogosyan, is a benign pigmented lesion similar to its cutaneous counterpart, in which melanin pigment is deposited in the cytoplasm of normal, hyperplastic or malignant stromal cells. Its identification is usually incidental, after a histopathological study. Its pathogenesis remains unclear and controversial, but the accepted hypothesis is that of the centrifugal migration of melanoblasts from the neural crest to the prostate during the embryonic period, resulting in their ectopic location in this organ and in others. Currently, 30 cases have been reported in the world literature.
Abstract and Introduction
Abstract
Introduction: Prostatic blue nevus was first described as a benign lesion of uncertain and controversial histogenesis by Nogogosyan in 1963. Currently, 30 cases have been reported in the world literature.
Case presentation: A 63-year-old Hispanic man presented with prostatism of several months' evolution. Histopathological examination revealed a blue nevus associated with nodular hyperplasia and acute inflammation.
Conclusion: Prostatic blue nevus is a rare and unusual, histologically benign prostatic lesion with limited clinical significance and a favorable prognosis.
Introduction
Melanocytic lesions, comprising blue nevi (BN), melanosis and malignant melanomas, are neoplastic processes observed, though rarely, in the prostate gland. Extracutaneous location of a BN is extremely unusual. There have been reports of BN in the spermatic cord, prostate, vagina, cervix, oral cavity, paranasal sinuses, larynx, breast, pulmonary hilum and lymph nodes.
Prostatic blue nevus (PBN), first described in 1963 by Nogogosyan, is a benign pigmented lesion similar to its cutaneous counterpart, in which melanin pigment is deposited in the cytoplasm of normal, hyperplastic or malignant stromal cells. Its identification is usually incidental, after a histopathological study. Its pathogenesis remains unclear and controversial, but the accepted hypothesis is that of the centrifugal migration of melanoblasts from the neural crest to the prostate during the embryonic period, resulting in their ectopic location in this organ and in others. Currently, 30 cases have been reported in the world literature.
