Drug-Induced Uveitis
Drug-Induced Uveitis
A number of drugs have been implicated as inciting agents for the development of uveitis in susceptible patients. Uveitis has been reported both with drugs administered locally, that is, via the topical or intraocular routes ( Table 1 ), and with systemically administered drugs ( Table 2 ). Most cases of drug-induced uveitis are believed to be immune-mediated; however, in some cases it is possible that direct chemical toxicity targeting the uveal tissue resulting, secondarily, in inflammation plays a role in the pathogenesis of drug-induced uveitis. Drug-associated uveitis may involve any anatomic compartment of the eye, with drug-associated anterior uveitis, intermediate uveitis, posterior uveitis, and panuveitis all having been reported. The purpose of this review is to provide an up-to-date synopsis on the drugs associated with uveitis. The drugs covered in this review are organized into the following categories: antimicrobial drugs, ocular hypotensive drugs, bisphosphonates, biologic drugs, vaccines, and miscellaneous drugs.
Abstract
A number of drugs have been implicated as inciting agents for the development of uveitis in susceptible patients. Uveitis has been reported both with drugs administered locally, that is, via the topical or intraocular routes ( Table 1 ), and with systemically administered drugs ( Table 2 ). Most cases of drug-induced uveitis are believed to be immune-mediated; however, in some cases it is possible that direct chemical toxicity targeting the uveal tissue resulting, secondarily, in inflammation plays a role in the pathogenesis of drug-induced uveitis. Drug-associated uveitis may involve any anatomic compartment of the eye, with drug-associated anterior uveitis, intermediate uveitis, posterior uveitis, and panuveitis all having been reported. The purpose of this review is to provide an up-to-date synopsis on the drugs associated with uveitis. The drugs covered in this review are organized into the following categories: antimicrobial drugs, ocular hypotensive drugs, bisphosphonates, biologic drugs, vaccines, and miscellaneous drugs.
