Ticagrelor vs Clopidogrel in Non-ST-Elevation ACS
Ticagrelor vs Clopidogrel in Non-ST-Elevation ACS
In this substudy of the PLATO trial, ticagrelor compared with clopidogrel consistently reduced the rates of ischaemic events and mortality without any difference in overall major bleeding in patients with an entry diagnosis of NSTE-ACS, and this effect was independent of whether or not early revascularization was performed. These results harmonize with the European Society of Cardiology (ESC) NSTE-ACS guidelines, which recommend ticagrelor in all patients at moderate-to-high risk of ischaemic events, regardless of initial treatment strategy.
Conclusions
In this substudy of the PLATO trial, ticagrelor compared with clopidogrel consistently reduced the rates of ischaemic events and mortality without any difference in overall major bleeding in patients with an entry diagnosis of NSTE-ACS, and this effect was independent of whether or not early revascularization was performed. These results harmonize with the European Society of Cardiology (ESC) NSTE-ACS guidelines, which recommend ticagrelor in all patients at moderate-to-high risk of ischaemic events, regardless of initial treatment strategy.
