Nutrient Supplementation
Nutrient Supplementation
Menevit is an oral antioxidant supplement consisting of vitamin C, vitamin E, zinc, folic acid, lycopene, garlic oil, and Se. In a prospective, randomized, double-blind trial involving 60 couples with severe male-factor infertility, a daily oral Menevit tablet taken for 3 months before the partner's in vitro fertilization cycle improved the viable pregnancy rate (38.5% of transferred embryos) compared with a placebo group (16% of transferred embryos).
Coenzyme Q10 (CoQ-10) is found endogenously in the sperm midpiece. It recycles vitamin E, controls its prooxidant capability, and is involved in energy production. In vitro incubation of semen samples of infertile men with 50 mM of CoQ-10 significantly increased sperm motility. Oral supplementation with 60 mg of CoQ-10 in these infertile men was seen to improve fertilization rate without affecting semen parameters. Catalase is another antioxidant that should be further investigated for its ability to detoxify both intracellular and extracellular hydrogen peroxide to water and oxygen. Other compounds involved in the regeneration of antioxidant stores, such as lipoic acid, may also be beneficial to enhance the effects of vitamins C and E as well as GSH.
Other
Menevit is an oral antioxidant supplement consisting of vitamin C, vitamin E, zinc, folic acid, lycopene, garlic oil, and Se. In a prospective, randomized, double-blind trial involving 60 couples with severe male-factor infertility, a daily oral Menevit tablet taken for 3 months before the partner's in vitro fertilization cycle improved the viable pregnancy rate (38.5% of transferred embryos) compared with a placebo group (16% of transferred embryos).
Coenzyme Q10 (CoQ-10) is found endogenously in the sperm midpiece. It recycles vitamin E, controls its prooxidant capability, and is involved in energy production. In vitro incubation of semen samples of infertile men with 50 mM of CoQ-10 significantly increased sperm motility. Oral supplementation with 60 mg of CoQ-10 in these infertile men was seen to improve fertilization rate without affecting semen parameters. Catalase is another antioxidant that should be further investigated for its ability to detoxify both intracellular and extracellular hydrogen peroxide to water and oxygen. Other compounds involved in the regeneration of antioxidant stores, such as lipoic acid, may also be beneficial to enhance the effects of vitamins C and E as well as GSH.
